All Articles Tagged As: antibodies
A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction. The findings are published in the open-access journal PLoS Pathogens on Oct. 6.
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Annually changing flu vaccines with their hit-and-miss effectiveness may soon give way to a single, near-universal flu vaccine, according to a new report from scientists at the Scripps Research Institute and the Dutch biopharmaceutical company Crucell. They describe an antibody that, in animal tests, can prevent or cure infections with a broad variety of influenza viruses, including seasonal and potentially pandemic strains.
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 | In a pair of new papers, researchers at the Biodesign Institute at Arizona State University demonstrated a simple means of improving the binding affinity of synthetic antibodies, composed of random peptides. They also used random peptide sequences spotted onto glass microarray slides to mine information concerning the active regions or epitopes of naturally occurring antibodies. ...> Full Article |
A team at the Institut de recherches cliniques de Montréal led by Dr. Tarik Möröy, president and scientific director of the institute and director of the hematopoiesis and cancer research unit, will be publishing an important breakthrough in tomorrow's issue of Immunity, a scientific journal from the Cell Press group. The researchers identified a new regulator playing a critical role in the development B cells, which produce antibodies.
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Lieb and his colleagues from across the country describe how they tested more than 200 antibodies against 57 histone modifications (or flavors) in three different organisms, using three different tests commonly used in this kind of genetic analysis. They found that about 25 percent of antibodies currently sold have a problem with specificity -- targeting the anticipated histone -- in a given test. They believe that this proportion is likely to remain steady over time.
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Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore. However, antibodies obtained from blood of animals such as mice could not be used: The human immune system recognizes them as foreign and rejects them. In an international cooperation, scientists from the Helmholtz Centre for Infection Research in Braunschweig, Germany have now succeeded in developing a promising approach to solve this problem.
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 | VTT Technical Research Centre of Finland has developed a method of using printing technology to produce simple tests related to health, well-being and the environment. VTT has demonstrated the efficacy of the method by printing a hemoglobin test, i.e. manufactured paper that reveals whether a given sample contains hemoglobin. ...> Full Article |
Researchers at the Biodesign Institute at Arizona State University have developed a much faster and simpler way of making synthetic antibodies, by carrying out the usual steps in reverse.
Stephen Albert Johnston and Chris Diehnelt have developed a technique for constructing peptide sequences, then linking them together to form a synthetic antibody, or synbody, that can bind with one or more protein molecules contained in the vast repository of human proteins -- the proteome.
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New antibodies and recombinant proteins with a key signaling role in immune response to disease have been produced through collaboration between molecular immunology institutes in the Czech Republic and Germany and a private company. The proteins have their own direct uses in immunization and are also the starting point for production of novel, highly specific antibodies with a wide range of biomedical applications. All of the new products are already being marketed commercially.
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